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=== 2.6.1 Geophysical Understanding === <div id="section-2-6-1-block-1"></div> Knowledge gaps are associated with the carbon cycle response, the role of non-CO <sub>2</sub> emissions and the evaluation of an appropriate historic baseline. Quantifying how the carbon cycle responds to negative emissions is an important knowledge gap for strong mitigation pathways (Section 2.2). Earth system feedback uncertainties are important to consider for the longer-term response, particularly in how permafrost melting might affect the carbon budget (Section 2.2). Future research and ongoing observations over the next years will provide a better indication as to how the 2006-2015 base period compares with the long-term trends and might at present bias the carbon budget estimates. The future emissions of short-lived climate forcers and their temperature response are a large source of uncertainty in 1.5°C pathways, having a greater relative uncertainty than in higher CO <sub>2</sub> emission pathways. Their global emissions, their sectoral and regional disaggregation, and their climate response are generally less well quantified than for CO <sub>2</sub> (Sections 2.2 and 2.3). Emissions from the agricultural sector, including land-use based mitigation options, in 1.5°C pathways constitute the main source of uncertainty here and are an important gap in understanding the potential achievement of stringent mitigation scenarios (Sections 2.3 and 2.4). This also includes uncertainties surrounding the mitigation potential of the long-lived GHG nitrous oxide (Sections 2.3 and 2.4). There is considerable uncertainty in how future emissions of aerosol precursors will affect the effective radiative forcing from aerosol–cloud interaction. The potential future warming from mitigation of these emissions reduces remaining carbon budgets and increases peak temperatures (Section 2.2). The potential co-benefits of mitigating air pollutants and how the reduction in air pollution may affect the carbon sink are also important sources of uncertainty (Sections 2.2 and 2.5). The pathway classification employed in this chapter employs results from the MAGICC model with its AR5 parameter sets. The alternative representation of the relationship between emissions and effective radiative forcing and response in the FAIR model would lead to a different classification that would make 1.5°C targets more achievable (Section 2.2 and Supplementary Material 2.SM.1.1). Such a revision would significantly alter the temperature outcomes for the pathways and, if the result is found to be robust, future research and assessments would need to adjust their classifications accordingly. Any possible high bias in the MAGICC response may be partly or entirely offset by missing Earth system feedbacks that are not represented in either climate emulator and that would act to increase the temperature response (Section 2.2). For this assessment report, any possible bias in the MAGICC setup applied in this and earlier reports is not established enough in the literature to change the classification approach. However, we only place ''medium confidence'' in the classification adopted by the chapter. <span id="integrated-assessment-approaches"></span>
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